Michelle de Graaf Selected Research

N- (4- doxorubicin- N- carbonyl(oxymethyl)phenyl)- O- glucuronyl carbamate

12/2004	A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy.
3/2004	Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein.

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Michelle de Graaf Research Topics

Disease

4	Neoplasms (Cancer) 12/2004 - 01/2002
1	Ovarian Neoplasms (Ovarian Cancer) 03/2004

Drug/Important Bio-Agent (IBA)

4	ProdrugsIBA 12/2004 - 01/2002
3	GlucuronidesIBA 12/2004 - 01/2002
2	N- (4- doxorubicin- N- carbonyl(oxymethyl)phenyl)- O- glucuronyl carbamateIBA 12/2004 - 03/2004
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2004 - 03/2004
2	GlucuronidaseIBA 12/2004 - 03/2004
2	EnzymesIBA 03/2004 - 06/2003
1	Phosphates (Orthophosphate)IBA 03/2004
1	Proteins (Proteins, Gene)FDA Link 03/2004
1	CarbamatesIBA 03/2004

Therapy/Procedure

1	Intravenous Administration 12/2004
1	Drug Therapy (Chemotherapy) 12/2004
1	Intravenous Injections 03/2004
1	Therapeutics 06/2003